Summary:
Folic acid is crucial for normal DNA synthesis and repair.
Folate deficiency may cause an imbalance in DNA precursors, uracil misincorporation into DNA, and chromosome breakage.
The paper below discusses epidemiological data supporting the involvement of folic acid in the aetiology of cancer.
It also assesses the evidence from cellular, animal and human studies that folic acid can modulate DNA by such mechanisms.
This is perhaps the highest referenced research paper on this subject.
***
Susan J Duthie
Division of Micronutrients and Lipid Metabolism, Rowett Research Institute, Aberdeen, UK
Folic acid deficiency in humans has been linked with megaloblastic anaemia,
neural tube defects in the neonate, and heart disease. Folate has also been
implicated in the development of cancer, especially cancer of the colorectum.
There appear to be two principal mechanisms through which low folate status
may increase the risk of malignancy. Folate deficiency, by reducing intracellular
S-adenosylmethionine (SAM), can alter cytosine methylation in DNA, leading to
inappropriate activation of proto-oncogenes and induction of malignant
transformation. Alternatively, folic acid is crucial for normal DNA synthesis and
repair. Folate deficiency may cause an imbalance in DNA precursors, uracil
misincorporation into DNA, and chromosome breakage. This chapter briefly
describes the epidemiological data supporting the involvement of folic acid in
the aetiology of cancer. It also assesses the evidence from cellular, animal and
human studies that folic acid can modulate DNA by such mechanisms.
Click on the pdf search result in the below google search result
Folic acid is crucial for normal DNA synthesis and repair.
Folate deficiency may cause an imbalance in DNA precursors, uracil misincorporation into DNA, and chromosome breakage.
The paper below discusses epidemiological data supporting the involvement of folic acid in the aetiology of cancer.
It also assesses the evidence from cellular, animal and human studies that folic acid can modulate DNA by such mechanisms.
This is perhaps the highest referenced research paper on this subject.
***
Susan J Duthie
Division of Micronutrients and Lipid Metabolism, Rowett Research Institute, Aberdeen, UK
Folic acid deficiency in humans has been linked with megaloblastic anaemia,
neural tube defects in the neonate, and heart disease. Folate has also been
implicated in the development of cancer, especially cancer of the colorectum.
There appear to be two principal mechanisms through which low folate status
may increase the risk of malignancy. Folate deficiency, by reducing intracellular
S-adenosylmethionine (SAM), can alter cytosine methylation in DNA, leading to
inappropriate activation of proto-oncogenes and induction of malignant
transformation. Alternatively, folic acid is crucial for normal DNA synthesis and
repair. Folate deficiency may cause an imbalance in DNA precursors, uracil
misincorporation into DNA, and chromosome breakage. This chapter briefly
describes the epidemiological data supporting the involvement of folic acid in
the aetiology of cancer. It also assesses the evidence from cellular, animal and
human studies that folic acid can modulate DNA by such mechanisms.
Click on the pdf search result in the below google search result
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