Summary:
The below two papers talk about link between alcohol intake and cancer.
The first paper says Alcohol intake tended to be associated inversely with colon cancer, but not with rectal cancer.
The second paper heavy alcohol use and breast cancer has been observed in most studies, even after controlling for known risk factors for breast cancer.
Alcohol has consistently been related to risks of squamous cell carcinomas of the mouth, oral pharynx, larynx, and esophagus in multiple studies of varying design.
My note: From this research paper (http://healthsummary.blogspot.in/2018/01/folic-acid-deficiency-and-cancer.html), we know that heavy alcohol causes folate deficiency. So, perhaps, heavy alcohol drinking must be causing cancers in those with low folate levels.
***
Tohoku J. Exp. Med., 1993, 171, 153-165
A Case-Control Study of Colorectal Cancer
and Its Relation to Diet, Cigarettes, and
Alcohol Consumption in Saitama Prefecture,
Japan
YOSHIHARU HOSHIYAMA, TAKESHI SEKINE * and TAKAFUMI
SASABA
Department of Epidemiology, Saitama Cancer Center
Research Institute, and *Saitama Cancer Center Hospital,
Saitama 362
HOSHIYAMA, Y., SEKINE, T. and SASABA, T.
A Case-Control Study of
Colorectal Cancer and Its Relation to Diet, Cigarettes, and Alcohol Consumption in
Saitama Prefecture, Japan. Tohoku J. Exp. Med., 1993, 171(2), 153-165 A
case-control study of colorectal cancer in relation to dietary, smoking, and drinking
habits was undertaken in Saitama Prefecture, Japan. The study was based on 181
newly diagnosed cases of adenocarcinoma of the colorectum at a single institution
and 653 general population controls.
Dietary habits were investigated on the
basis of the intake of 12 foods and 12 food groups in a food intake frequency
questionnaire, together with individual food preferences.
Preference for salty
foods was positively related to the risk of both colon and rectal cancer, and the
consumption of seaweed was inversely related to these cancers, both with a
dose-response relation.
Cigarette smoking was inversely related to colon cancer
risk, but not to rectal cancer risk.
Alcohol intake tended to be associated inversely
with colon cancer, but not with rectal cancer.
In the multiple logistic regression,
preference for salty foods (positively) and the consumption of seaweed (inversely)
were independently related to both colon and rectal cancer risks, alcohol;
case-control study; colorectal cancer; diet; smoking.
https://pdfs.semanticscholar.org/6cbc/0388f658aa1201ec299b1eca0ece07f2c962.pdf
***
David B. Thomas
The Fred Hutchinson Cancer Research Center, Seattle, Washington
This is a review of the epidemiologic literature on alcohol and risks of various cancers.
Alcohol has consistently been related to risks of squamous cell carcinomas of the mouth, oral pharynx, larynx, and esophagus in multiple studies of varying design.
The joint effects of alcohol and smoking are
greater than additive, and are probably multiplicative, suggesting biological synergism. All major types of alcoholic beverages have been causally implicated in the genesis of these diseases. The influence of alcohol on risks of upper aerodigestive tract cancers may be greater in persons with
marginal nutritional status than in better-nourished individuals. Alcohol also has been associated with an increased risk of adenocarcinomas of the esophagus, gastro-esophageal junction, and gastric cardia, but the relationship is not as strong as for squamous cell esophageal carcinomas.
Alcohol
and tobacco account for over 80% of the squamous carcinomas of the mouth, pharynx, larynx, and esophagus in the United States.
Risks of cancers of the distal stomach, pancreas, colon, and rectum have not been consistently related to alcohol, although possible relationships between
beer drinking and rectal cancer and between heavy use of alcohol and pancreatic cancer warrant further study.
Studies of alcohol and liver cancer, in which the confounding influence of hepatitis B was considered, have yielded inconsistent results and should be replicated.
An association between
heavy alcohol use and breast cancer has been observed in most studies, even after controlling for known risk factors for breast cancer, and additional investigations of this issue are warranted. - Environ Health Perspect 103(Suppl 8):153-160 (1995)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1518951/pdf/envhper00368-0156.pdf
The below two papers talk about link between alcohol intake and cancer.
The first paper says Alcohol intake tended to be associated inversely with colon cancer, but not with rectal cancer.
The second paper heavy alcohol use and breast cancer has been observed in most studies, even after controlling for known risk factors for breast cancer.
Alcohol has consistently been related to risks of squamous cell carcinomas of the mouth, oral pharynx, larynx, and esophagus in multiple studies of varying design.
My note: From this research paper (http://healthsummary.blogspot.in/2018/01/folic-acid-deficiency-and-cancer.html), we know that heavy alcohol causes folate deficiency. So, perhaps, heavy alcohol drinking must be causing cancers in those with low folate levels.
***
Tohoku J. Exp. Med., 1993, 171, 153-165
A Case-Control Study of Colorectal Cancer
and Its Relation to Diet, Cigarettes, and
Alcohol Consumption in Saitama Prefecture,
Japan
YOSHIHARU HOSHIYAMA, TAKESHI SEKINE * and TAKAFUMI
SASABA
Department of Epidemiology, Saitama Cancer Center
Research Institute, and *Saitama Cancer Center Hospital,
Saitama 362
HOSHIYAMA, Y., SEKINE, T. and SASABA, T.
A Case-Control Study of
Colorectal Cancer and Its Relation to Diet, Cigarettes, and Alcohol Consumption in
Saitama Prefecture, Japan. Tohoku J. Exp. Med., 1993, 171(2), 153-165 A
case-control study of colorectal cancer in relation to dietary, smoking, and drinking
habits was undertaken in Saitama Prefecture, Japan. The study was based on 181
newly diagnosed cases of adenocarcinoma of the colorectum at a single institution
and 653 general population controls.
Dietary habits were investigated on the
basis of the intake of 12 foods and 12 food groups in a food intake frequency
questionnaire, together with individual food preferences.
Preference for salty
foods was positively related to the risk of both colon and rectal cancer, and the
consumption of seaweed was inversely related to these cancers, both with a
dose-response relation.
Cigarette smoking was inversely related to colon cancer
risk, but not to rectal cancer risk.
Alcohol intake tended to be associated inversely
with colon cancer, but not with rectal cancer.
In the multiple logistic regression,
preference for salty foods (positively) and the consumption of seaweed (inversely)
were independently related to both colon and rectal cancer risks, alcohol;
case-control study; colorectal cancer; diet; smoking.
https://pdfs.semanticscholar.org/6cbc/0388f658aa1201ec299b1eca0ece07f2c962.pdf
***
David B. Thomas
The Fred Hutchinson Cancer Research Center, Seattle, Washington
This is a review of the epidemiologic literature on alcohol and risks of various cancers.
Alcohol has consistently been related to risks of squamous cell carcinomas of the mouth, oral pharynx, larynx, and esophagus in multiple studies of varying design.
The joint effects of alcohol and smoking are
greater than additive, and are probably multiplicative, suggesting biological synergism. All major types of alcoholic beverages have been causally implicated in the genesis of these diseases. The influence of alcohol on risks of upper aerodigestive tract cancers may be greater in persons with
marginal nutritional status than in better-nourished individuals. Alcohol also has been associated with an increased risk of adenocarcinomas of the esophagus, gastro-esophageal junction, and gastric cardia, but the relationship is not as strong as for squamous cell esophageal carcinomas.
Alcohol
and tobacco account for over 80% of the squamous carcinomas of the mouth, pharynx, larynx, and esophagus in the United States.
Risks of cancers of the distal stomach, pancreas, colon, and rectum have not been consistently related to alcohol, although possible relationships between
beer drinking and rectal cancer and between heavy use of alcohol and pancreatic cancer warrant further study.
Studies of alcohol and liver cancer, in which the confounding influence of hepatitis B was considered, have yielded inconsistent results and should be replicated.
An association between
heavy alcohol use and breast cancer has been observed in most studies, even after controlling for known risk factors for breast cancer, and additional investigations of this issue are warranted. - Environ Health Perspect 103(Suppl 8):153-160 (1995)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1518951/pdf/envhper00368-0156.pdf
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