Am J Gastroenterol. 1987 Mar;82(3):211-4.
Effect of red pepper and black pepper on the stomach.
Myers BM, Smith JL, Graham DY.
Abstract
Spices have long been implicated as a cause of gastric mucosal injury. We assessed the effects of red and black pepper on the gastric mucosa using double-blind intragastric administration of test meals containing red pepper (0.1-1.5 g) or black pepper (1.5 g) to healthy human volunteers; aspirin (655 mg) and distilled water were used as positive and negative controls, respectively.
Serial gastric washes were performed after test meal administration and gastric contents were analyzed for DNA, pepsin, blood, sodium, potassium, parietal cell secretion, and nonparietal cell secretion.
Both red pepper and black pepper caused significant increases in parietal secretion, pepsin secretion, and potassium loss.
Gastric cell exfoliation (as reflected in DNA loss into gastric contents) was increased after red or black pepper administration; the increase after red pepper administration was dose dependent.
Mucosal microbleeding was seen after spice administration and one subject had grossly visible gastric bleeding after both red pepper and black pepper administration. There were no significant differences from control between the test meals, in nonparietal volume, fractional recovery of the gastric secretions, or sodium secretion.
Finally, no spice was significantly different from aspirin in any parameter studied; indeed, aspirin was comparable to the higher doses of pepper. The long-term result of daily pepper ingestion is unknown. Whether spices are detrimental, beneficial (e.g., inducing an adaptive cytoprotective response), or have no significant long-term effect on the gastric mucosa is unknown and deserves further study.
https://www.ncbi.nlm.nih.gov/pubmed/3103424
Effect of red pepper and black pepper on the stomach.
Myers BM, Smith JL, Graham DY.
Abstract
Spices have long been implicated as a cause of gastric mucosal injury. We assessed the effects of red and black pepper on the gastric mucosa using double-blind intragastric administration of test meals containing red pepper (0.1-1.5 g) or black pepper (1.5 g) to healthy human volunteers; aspirin (655 mg) and distilled water were used as positive and negative controls, respectively.
Serial gastric washes were performed after test meal administration and gastric contents were analyzed for DNA, pepsin, blood, sodium, potassium, parietal cell secretion, and nonparietal cell secretion.
Both red pepper and black pepper caused significant increases in parietal secretion, pepsin secretion, and potassium loss.
Gastric cell exfoliation (as reflected in DNA loss into gastric contents) was increased after red or black pepper administration; the increase after red pepper administration was dose dependent.
Mucosal microbleeding was seen after spice administration and one subject had grossly visible gastric bleeding after both red pepper and black pepper administration. There were no significant differences from control between the test meals, in nonparietal volume, fractional recovery of the gastric secretions, or sodium secretion.
Finally, no spice was significantly different from aspirin in any parameter studied; indeed, aspirin was comparable to the higher doses of pepper. The long-term result of daily pepper ingestion is unknown. Whether spices are detrimental, beneficial (e.g., inducing an adaptive cytoprotective response), or have no significant long-term effect on the gastric mucosa is unknown and deserves further study.
https://www.ncbi.nlm.nih.gov/pubmed/3103424
powders (T3). Feed intake, body weight gain, feed conversion ratio were determined. At the end of trial 4 chicks form each group were separated and slaughtered. Cholesterol, triglyceride, glucose levels and antibody titer against new castle vaccine were investigated. The result revealed that the inclusion of red and black pepper in broilers diet improved body weight gain, feed intake and conversion ratio. in addition use of red and black pepper depressed the cholesterol, triglyceride and glucose concentration and decreased H/L ratio concentration in broiler's blood plasma (p<0.05). mucosa and sub mucosa diameters of small intestine were significantly increased (p<0.05).
musclaris (is a thin layer (lamina) of muscle of the gastrointestinal tract, located outside the lamina propria and separating it from the submucosa) and
serosa diameters ( is a smooth tissue membrane consisting of two layers of mesothelium, which secrete serous fluid) were higher in T1, and T3 than control groups. Data from this study showed use of red and black pepper powder on broilers diets cause increase total diameter of small intestine parts (p<0.05).It was concluded that the use of red and black pepper as feed additive at 1% enhanced the overall performance of broiler chicks.
